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KMID : 0043319940170020060
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.60 ~ p.65
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Synthesis and Quartemization of 6-(Substitutedamino)-Purines with Antitumor Activity Screening
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El-Bayouki Khairy-A.M.
Basyouni Wahid-M.
El-Din S.M.
Habeeb A.G.
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Abstract
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Reaction of c-chloro-9-benzyl-8-(methylthio)purine 3 with primary amines afforoded, the comesponding 6-(substitutedamino)purines 4a-g. The latter products when methylated with methyl iodide yielded smoothly -methyl purinium iodide salts 5a-f rather than the probable -derivatives. 9-Benzyl-3-methyl-6-(methylmino)-8-(methylthio)purine 8 was obtained upon treating the purinium iodide 5a with alkali. Most of the synthesized compounds were screened for their antitumor activity.
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KEYWORD
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Substifutedamino-purines, Quartemization, Antitumor activity
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